Making it simple: Imagine you are making a colorful necklace. Each bead represents a nucleotide - a sugar and a phosphate group with a base (we will talk more about this base later). You string the beads together one by one, connecting them at two points - the phosphate of one bead and the sugar of the next bead. This sequence of sugar and phosphate makes up the backbone of your necklace. But instead of a necklace, you're creating a DNA or RNA molecule!

• Sugar-phosphate bonding is like a handshake between two friends, where the phosphate of one nucleotide and the sugar of the next nucleotide form a strong connection, or a covalent bond. This handshake is made by every living organism to produce nucleic acids (DNA and RNA).

• Just think about baking a cake. You cannot add the eggs before you mix the flour and sugar. The same is with nucleotides. The new nucleotide is always added to the growing chain by its phosphate connecting to the sugar of the previous nucleotide.

• It's important to note that these are covalent bonds, they are super strong bonds where atoms share electrons. Think of it like sharing your favorite toy with your best friend. You are bonded to your best friend as atoms are bonded in covalent bonds!