Alright, budding biologist! Let's unwrap the enigma of the tertiary structure of proteins, but first, imagine this: The proteins in your body are like unique 3D puzzles. Each piece, when fit perfectly, forms a masterpiece. But what holds these pieces together? Let's find out!

• Think of a long string of beads. This string can twist and turn, taking on an intricate 3D shape. That's the tertiary structure of a protein!
• It's how the entire polypeptide chain folds itself into a complex 3D shape.

• Formed between charged R-groups.
• Example: Amine groups can snag a proton and become positive (–NH₂ + H+ = –NH₃+). On the flip side, carboxyl groups, when feeling generous, donate a proton, becoming negative (–COOH = –COO− + H+).
• Real-World Tie-in: Think of ionic bonds like magnets. Positive attracts negative. If you've ever played with magnets, you know that they can either attract or repel depending on their charges. In proteins, these ionic bonds keep certain parts of the protein close together.
• Fun Fact! 🎉 These bonds are drama queens. Change the pH, and they might just change their attitude!