🔵 Polar/Charged Amino Acids (Hydrophilic)
- These love water! 💧 - Imagine them as the outgoing party-goers who like to hang out near the pool at a summer party.

🔴 Non-Polar Amino Acids (Hydrophobic)
- They prefer to avoid water. - Think of them as those folks who'd rather stay indoors, away from the water games.

• Located either in the cytoplasm or in some watery area outside cells.
• Setting up the Scene: The exterior walls of the house (the protein surface) have the hydrophilic amino acids, since they're in contact with water. The introverted, hydrophobic amino acids? They’re chilling in the center of the party, away from the water.
• Why this setup? It's like arranging the seating to avoid drama! This configuration stabilizes the protein structure.

• Some proteins frequently mingle with non-polar substances.
• They have hydrophobic amino acids on parts of their surface, like decking for a house.
• Example: Integral proteins in cell membranes are like houses built over water. The hydrophobic parts touch the non-polar core of the membrane. Just like stilts on a waterfront house, it keeps them stable and positioned correctly.

• These are proteins that go across the membrane.
• Their setup is like a house with a front yard (hydrophilic), a main indoor area (hydrophobic belt), and a backyard (hydrophilic).
• Bonus: This design ensures the protein stays in the right spot in the membrane and does its job efficiently.