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Page Facing Up

Theme B - Form & Function

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Direct Hit

Theme A - Unity & diversity

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Pill

Theme C - Interaction &  Interdependence

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Keycap Digit One

Theme D - Continuity & Change

<ul>
	<li>Golgi Apparatus: A stack of flattened, pancake-like sacs (called cisternae).</li>
	<li>Main Role: Processes polypeptides made by the rough endoplasmic reticulum (rER).</li>
</ul>

<ul>
	<li>Transport: Polypeptides hitch a ride from the rER inside tiny bubble-like vesicles.</li>
	<li>Remodeling: Imagine polypeptides as blank t-shirts. Inside the cisternae, they get designed! They:
	<ul>
		<li>Might get a &#39;carbohydrate sticker&#39; making them a glycoprotein.</li>
		<li>Sometimes, a sprinkle of phosphate or sulfate is added for an extra touch.</li>
	</ul>
	</li>
	<li>Team Assembly: Polypeptides can join others to establish the quaternary structure of proteins. Think of it like building a LEGO set from different pieces!</li>
</ul>

Once a protein&#39;s makeover is complete, it&#39;s packed and sent off in a vesicle to

<ul>
	<li>Lysosome or a food vacuole (like a recycling center or a food pantry).</li>
	<li>Plasma membrane if it&#39;s being secreted out. For example, imagine pancreas cells sending out digestive enzymes like chefs delivering food!</li>
</ul>

It&#39;s like an assembly line! Proteins move through cisternae, starting from the side closest to rER (cis side) and finishing on the opposite side (trans side).

Two theories

<ul>
	<li>Vesicle Transport Model: Cisternae are like fixed stations, and vesicles are like buses moving proteins between them.</li>
	<li>Cisternal Maturation Model: It&#39;s a bit like an escalator. Vesicles from rER become new cisternae on the cis side. Then they &#39;travel&#39; through the Golgi and finally, turn into vesicles at the trans side.</li>
</ul>

The &quot;escalator&quot; model (Cisternal Maturation) seems to have the edge right now, but there&#39;s still a lot of mystery. For instance, why are the cisternae stacked up? It&#39;s one of the unsolved riddles of the cell world!

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Real-World Analogy: Imagine the Golgi Apparatus as a bustling post office. Letters (polypeptides) come in, get sorted, stamped (processed), and then sent off to their final destinations. Some go to nearby towns (lysosomes), while others are flown overseas (secreted out of the cell). Just as there are theories about the best ways to handle mail, we have models about how proteins navigate through the Golgi!

Theme B - Form & Function

Unlocking The Mysteries Of The Golgi Apparatus

Table of content

What is it? 📦

Journey of a polypeptide 🚖

End of the trip? 🎁

Unlock the Full Content!

Theme B - Form & Function

Unlocking The Mysteries Of The Golgi Apparatus

Table of content

What is it? 📦

Journey of a polypeptide 🚖

End of the trip? 🎁

Unlock the Full Content!