Yo future biologists, let's dive into something super cool: allele frequencies in different populations! We're looking at alcohol dehydrogenase alleles (ADH 1B *1 and ADH 1B *2) and how they differ across the globe. It's not just bookish knowledge; it could explain why your buddy can't handle their booze! 🍺🤢

• What's an Allele?: Think of an allele as a version of a gene. Like, you have different models of iPhones, right? Same deal!

• Allele Frequency: This is how often a particular allele shows up in a population.

• Diversity Across Ethnic Groups: Some alleles are like superstars in one region but practically non-existent in others. That's like how K-Pop is huge in Korea but might not be everyone's jam in, let's say, rural Texas.

• AlFred Database: The Allele Frequency Database (AlFred) at Yale is your go-to source for comparing allele frequencies globally. 🌐

Real-World Example 🌏

Imagine you're a fan of a local band. In your city, everyone loves them (high frequency), but if you go to a different city, they might not even know the band's name (low frequency).

• Function: Breaks down alcohol in the liver. Yep, this is the stuff that saves you from being eternally drunk!

• **ADH 1B 1 vs. ADH 1B 2

  • *1 is the party animal 🎉, more common in heavy drinkers.
  • *2 is the efficient worker 🤓, metabolizes alcohol super-fast.

Real-World Example 🥳

Think of these alleles like car engines

• *1 is a gas-guzzler, inefficient but keeps running.
• *2 is an electric car, super-efficient and eco-friendly!