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Pill

Theme C - Interaction &  Interdependence

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Direct Hit

Theme A - Unity & Diversity

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Page Facing Up

Theme B - Form & Function

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Keycap Digit One

Theme D - Continuity & Change

Enzymes are like nature&#39;s speed-dating service! They bring substrates together at their active site to make the magic happen. This union makes chemical reactions go faster.

Approaching the Active Site: When a basketball player tries to shoot, they don&rsquo;t always aim directly at the hoop. They adjust as they get closer. Similarly, a substrate approaches an enzyme in a random direction, but as it gets close, the enzyme&#39;s surface lures it in, guiding it to the active site.

<ul>
	<li>Once upon a time, we thought of enzymes and substrates like keys and locks - a perfect fit from the start.</li>
	<li>🚫 But wait! That&#39;s not exactly right. When the substrate comes close, both it and the enzyme&#39;s active site change shape a bit. Imagine trying to fit a slightly bent key into a lock, and the lock adjusts itself to accommodate. This shape-shifting act is what we call Induced-fit binding.</li>
</ul>

<ul>
	<li>Sometimes, there&#39;s a second substrate. It approaches, and like before, both it and the active site adjust their shapes to fit perfectly.</li>
	<li>Real-world example: Think of a double date. The first couple (first substrate and active site) is already dancing, and the second couple (second substrate and a different part of the active site) joins in. They all adjust to dance in harmony!</li>
</ul>

<ul>
	<li>When the substrate molecules change shape, it&#39;s easier for bonds to break and new ones to form. This transforms our substrate &#39;ingredients&#39; into final products.</li>
	<li>Example: Consider a Lego castle. Initially, you have separate blocks (substrates), but with the right connections (enzyme&rsquo;s help), you build a castle (product)!</li>
</ul>

<ul>
	<li>Once the products are formed, they wave goodbye and leave the active site.</li>
	<li>With the products gone, the enzyme&#39;s active site feels a bit lonely (and returns to its original shape). It&#39;s ready for another round of action, welcoming new substrates.</li>
</ul>

📝 Remember! The beauty of enzymes lies in their ability to speed up reactions again and again without getting used up. It&#39;s like having a rechargeable battery that rarely runs out of juice!

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Happy Studying! 🌟📖🧠

Theme C - Interaction & Interdependence

Induced-Fit Binding: How Substrates Activate Enzymes

Table of content

The basics 🚀

Think of an enzyme-substrate relationship like a basketball game 🏀

The old 'key & lock' model 🔑